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GLASS

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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	1-Benzyl-4-phenyl-decahydro-quinolin-4-ol
Molecular formula	C22H27NO
IUPAC name	1-benzyl-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-4-ol
Molecular weight	321.464
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.3
Synonyms	4-phenyl-1-(phenylmethyl)-2,3,4a,5,6,7,8,8a-octahydroquinolin-4-ol;hydrochloride CTK7J7798 1-benzyl-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-4-ol;hydrochloride BAS 02785769 Oprea1_679884 1-Benzyl-4-phenyldecahydro-4-quinolinol # CHEMBL1620460 STL433393 MLS000562811 BDBM42541 Quinolin-4-ol, perhydro-1-benzyl-4-phenyl- 1-benzyl-4-phenyldecahydroquinolin-4-ol cid_12004707 1-benzyl-4-phenyl-2,3,4a,5,6,7,8,8a-octahydroquinolin-4-ol AC1LBT78 MolPort-001-983-333 1-Benzyl-4-phenyldecahydro-4-quinolinol BIWOHGQOCMGKSL-UHFFFAOYSA-N SMR000177702 [ Show all ]
Inchi Key	BIWOHGQOCMGKSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27NO/c24-22(19-11-5-2-6-12-19)15-16-23(17-18-9-3-1-4-10-18)21-14-8-7-13-20(21)22/h1-6,9-12,20-21,24H,7-8,13-17H2
PubChem CID	563820
ChEMBL	N/A
IUPHAR	N/A
BindingDB	42541
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10170.0 nM	N/A	BindingDB

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