Function Annotation for BL0227996

Receptor Information
PDB ID 4eiy
Chain A
Resolution 1.8 Å
UniProt ID P29274 (Adenosine receptor A2a)
Ligand Binding/Catalytic Sites
Ligand Information
ID Name (Show Synonyms) Chemaxon Viewer Binding Affinity
Ligand-Protein Interaction
Global View, download receptor, ligand Local View Binding Site Residues
L48 D52 S91 N280 S281
Catalytic Site Residues N/A
Enzyme Commission
EC Number Name
Gene Ontology
GO Terms Name Ontology
GO:0000139 Golgi membrane Cellular Component
GO:0001609 G-protein coupled adenosine receptor activity Molecular Function
GO:0001963 synaptic transmission, dopaminergic Biological Process
GO:0001973 adenosine receptor signaling pathway Biological Process
GO:0001975 response to amphetamine Biological Process
GO:0004871 signal transducer activity Molecular Function
GO:0004930 G-protein coupled receptor activity Molecular Function
GO:0005506 iron ion binding Molecular Function
GO:0005515 protein binding Molecular Function
GO:0005882 intermediate filament Cellular Component
GO:0005886 plasma membrane Cellular Component
GO:0005887 integral to plasma membrane Cellular Component
GO:0006171 cAMP biosynthetic process Biological Process
GO:0006355 regulation of transcription, DNA-dependent Biological Process
GO:0006469 negative regulation of protein kinase activity Biological Process
GO:0006909 phagocytosis Biological Process
GO:0006915 apoptotic process Biological Process
GO:0006954 inflammatory response Biological Process
GO:0006968 cellular defense response Biological Process
GO:0007165 signal transduction Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Biological Process
GO:0007186 G-protein coupled receptor signaling pathway Biological Process
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway Biological Process
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway Biological Process
GO:0007190 activation of adenylate cyclase activity Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway Biological Process
GO:0007267 cell-cell signaling Biological Process
GO:0007271 synaptic transmission, cholinergic Biological Process
GO:0007417 central nervous system development Biological Process
GO:0007596 blood coagulation Biological Process
GO:0007600 sensory perception Biological Process
GO:0007626 locomotory behavior Biological Process
GO:0008015 blood circulation Biological Process
GO:0008285 negative regulation of cell proliferation Biological Process
GO:0009055 electron carrier activity Molecular Function
GO:0012505 endomembrane system Cellular Component
GO:0014049 positive regulation of glutamate secretion Biological Process
GO:0014057 positive regulation of acetylcholine secretion Biological Process
GO:0014061 regulation of norepinephrine secretion Biological Process
GO:0014069 postsynaptic density Cellular Component
GO:0016020 membrane Cellular Component
GO:0016021 integral to membrane Cellular Component
GO:0019899 enzyme binding Molecular Function
GO:0020037 heme binding Molecular Function
GO:0022900 electron transport chain Biological Process
GO:0030424 axon Cellular Component
GO:0030425 dendrite Cellular Component
GO:0030673 axolemma Cellular Component
GO:0030819 positive regulation of cAMP biosynthetic process Biological Process
GO:0031000 response to caffeine Biological Process
GO:0031802 type 5 metabotropic glutamate receptor binding Molecular Function
GO:0032230 positive regulation of synaptic transmission, GABAergic Biological Process
GO:0032279 asymmetric synapse Cellular Component
GO:0035249 synaptic transmission, glutamatergic Biological Process
GO:0035810 positive regulation of urine volume Biological Process
GO:0035815 positive regulation of renal sodium excretion Biological Process
GO:0040013 negative regulation of locomotion Biological Process
GO:0042311 vasodilation Biological Process
GO:0042493 response to drug Biological Process
GO:0042597 periplasmic space Cellular Component
GO:0042734 presynaptic membrane Cellular Component
GO:0042755 eating behavior Biological Process
GO:0043025 neuronal cell body Cellular Component
GO:0043116 negative regulation of vascular permeability Biological Process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Biological Process
GO:0043279 response to alkaloid Biological Process
GO:0043524 negative regulation of neuron apoptotic process Biological Process
GO:0044446 intracellular organelle part Cellular Component
GO:0045211 postsynaptic membrane Cellular Component
GO:0046636 negative regulation of alpha-beta T cell activation Biological Process
GO:0046982 protein heterodimerization activity Molecular Function
GO:0048011 nerve growth factor receptor signaling pathway Biological Process
GO:0048143 astrocyte activation Biological Process
GO:0048167 regulation of synaptic plasticity Biological Process
GO:0048786 presynaptic active zone Cellular Component
GO:0048812 neuron projection morphogenesis Biological Process
GO:0050714 positive regulation of protein secretion Biological Process
GO:0050728 negative regulation of inflammatory response Biological Process
GO:0051881 regulation of mitochondrial membrane potential Biological Process
GO:0051899 membrane depolarization Biological Process
GO:0051968 positive regulation of synaptic transmission, glutamatergic Biological Process
GO:0060079 regulation of excitatory postsynaptic membrane potential Biological Process
GO:0060080 regulation of inhibitory postsynaptic membrane potential Biological Process
GO:0060134 prepulse inhibition Biological Process
External Links

Jianyi Yang, Ambrish Roy and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).