SEQ2FUN

BioLiP
Download all results in tab-seperated text for 1072681 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
  • Sort results by
    << < 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 > >>
    Go to page

    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    41401 1p93:C (2.7) BS02 peptide ? N/A P04150 12686538
    41402 1p93:C (2.7) BS03 DEX ? N/A P04150 12686538 BindingDB: EC50=2.5nM, Ki=1.2nM, IC50=5nM, Kd=19nM
    41403 1p93:D (2.7) BS01 peptide ? N/A P04150 12686538
    41404 1p93:D (2.7) BS02 DEX ? N/A P04150 12686538 BindingDB: EC50=2.5nM, Ki=1.2nM, IC50=5nM, Kd=19nM
    41405 1p99:A (1.7) BS01 GLY ? N/A A0A0H3JTG5 15610013
    41406 1p99:A (1.7) BS02 MET ? N/A A0A0H3JTG5 15610013
    41407 1p9b:A (2.0) BS01 MG 6.3.4.4 GO:0000166 ... Q9U8D3 14729341
    41408 1p9b:A (2.0) BS02 IMO 6.3.4.4 GO:0000166 ... Q9U8D3 14729341
    41409 1p9b:A (2.0) BS03 HDA 6.3.4.4 GO:0000166 ... Q9U8D3 14729341
    41410 1p9b:A (2.0) BS04 GDP 6.3.4.4 GO:0000166 ... Q9U8D3 14729341
    41411 1p9e:A (2.4) BS01 ZN 3.1.8.1 N/A Q841S6 16181636
    41412 1p9e:A (2.4) BS02 ZN 3.1.8.1 N/A Q841S6 16181636
    41413 1p9e:B (2.4) BS01 ZN 3.1.8.1 N/A Q841S6 16181636
    41414 1p9e:B (2.4) BS02 CD 3.1.8.1 N/A Q841S6 16181636
    41415 1p9l:A (2.3) BS01 NAI 1.17.1.8 GO:0005737 ... P9WP23 12962488
    41416 1p9l:A (2.3) BS02 PDC 1.17.1.8 GO:0005737 ... P9WP23 12962488
    41417 1p9l:B (2.3) BS01 NAI 1.17.1.8 GO:0005737 ... P9WP23 12962488
    41418 1p9l:B (2.3) BS02 PDC 1.17.1.8 GO:0005737 ... P9WP23 12962488
    41419 1p9p:A (2.5) BS01 SAH 2.1.1.228 GO:0000287 ... P0A873 14583191 MOAD: Kd=68nM
    41420 1p9r:A (2.5) BS01 ZN 7.4.2.8 GO:0005524 ... P37093 14556751
    41421 1p9u:B (2.37) BS01 peptide 2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.6.4.12
    3.6.4.13
    4.6.1.-
    GO:0008233 ... P0C6Y5 12746549
    41422 1p9u:F (2.37) BS01 peptide 2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.6.4.12
    3.6.4.13
    4.6.1.-
    GO:0008233 ... P0C6Y5 12746549
    41423 1p9w:A (2.7) BS01 ZN 7.4.2.8 GO:0005524 ... P37093 14556751
    41424 1p9w:A (2.7) BS02 ANP 7.4.2.8 GO:0005524 ... P37093 14556751
    41425 1pa2:A (1.45) BS01 CA 1.11.1.7 GO:0002215 ... Q42578 11117266
    41426 1pa2:A (1.45) BS02 CA 1.11.1.7 GO:0002215 ... Q42578 11117266
    41427 1pa2:A (1.45) BS03 HEM 1.11.1.7 GO:0002215 ... Q42578 11117266
    41428 1pa6:A (2.45) BS01 dna ? GO:0000723 ... P29549 12912928
    41429 1pa6:A (2.45) BS02 dna ? GO:0000723 ... P29549 12912928
    41430 1pa6:B (2.45) BS01 dna ? GO:0000781 ... P16458 12912928
    41431 1pa9:A (2.0) BS01 CSN 3.1.3.48 GO:0004725 ... P15273 12810712 MOAD: Ki=25uM
    41432 1paa:A (-1.00) BS01 ZN ? N/A P07248 8161501
    41433 1pad:A (2.8) BS01 peptide 3.4.22.2 GO:0006508 ... P00784 952885
    41434 1pae:X (2.7) BS01 SE 2.7.4.6 GO:0004550 ... P22887 14604526
    41435 1pae:X (2.7) BS02 SE 2.7.4.6 GO:0004550 ... P22887 14604526
    41436 1pag:A (2.8) BS01 FMP 3.2.2.22 GO:0017148 ... P10297 8411176
    41437 1pag:B (2.8) BS01 FMP 3.2.2.22 GO:0017148 ... P10297 8411176
    41438 1pah:A (2.0) BS01 FE 1.14.16.1 GO:0004497 ... P00439 9406548
    41439 1pal:A (1.65) BS01 CA ? GO:0005509 ... P02619 1880797
    41440 1pal:A (1.65) BS02 CA ? GO:0005509 ... P02619 1880797
    41441 1pal:A (1.65) BS03 NH4 ? GO:0005509 ... P02619 1880797
    41442 1pam:A (1.8) BS01 CA 2.4.1.19 GO:0003824 ... P05618 15299574
    41443 1pam:A (1.8) BS02 CA 2.4.1.19 GO:0003824 ... P05618 15299574
    41444 1pam:B (1.8) BS01 CA 2.4.1.19 GO:0003824 ... P05618 15299574
    41445 1pam:B (1.8) BS02 CA 2.4.1.19 GO:0003824 ... P05618 15299574
    41446 1par:A (2.6) BS01 dna ? GO:0003677 ... P03050 8107872
    41447 1par:A (2.6) BS02 dna ? GO:0003677 ... P03050 8107872
    41448 1par:B (2.6) BS01 dna ? GO:0003677 ... P03050 8107872
    41449 1par:B (2.6) BS02 dna ? GO:0003677 ... P03050 8107872
    41450 1par:C (2.6) BS01 dna ? GO:0003677 ... P03050 8107872
    41451 1par:C (2.6) BS02 dna ? GO:0003677 ... P03050 8107872
    41452 1par:D (2.6) BS01 dna ? GO:0003677 ... P03050 8107872
    41453 1par:D (2.6) BS02 dna ? GO:0003677 ... P03050 8107872
    41454 1pau:A (2.5) BS01 peptide 3.4.22.56 GO:0004197 ... P42574 8673606
    41455 1pau:B (2.5) BS01 peptide 3.4.22.56 GO:0004197 ... P42574 8673606
    41456 1pax:A (2.4) BS01 DHQ 2.4.2.-
    2.4.2.30
    GO:0003950 ... P26446 8755499
    41457 1paz:A (1.55) BS01 CU ? GO:0005507 ... P04377 3271558
    41458 1pb0:A (1.95) BS01 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41459 1pb0:A (1.95) BS02 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41460 1pb0:A (1.95) BS03 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41461 1pb0:B (1.95) BS01 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41462 1pb0:B (1.95) BS02 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41463 1pb0:B (1.95) BS03 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41464 1pb0:C (1.95) BS01 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41465 1pb0:C (1.95) BS02 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41466 1pb0:C (1.95) BS03 ZN 3.1.3.- GO:0003824 ... P75914 N/A
    41467 1pb5:A (-1.00) BS01 CA ? N/A P46531 12795601
    41468 1pb7:A (1.35) BS01 GLY ? GO:0015276 ... P35439 12805203 BindingDB: IC50=6200nM
    41469 1pb8:A (1.45) BS01 DSN ? GO:0015276 ... P35439 12805203 MOAD: Ki=7.02uM
    BindingDB: IC50=670.0nM
    41470 1pb9:A (1.6) BS01 4AX ? GO:0015276 ... P35439 12805203 MOAD: Ki=241uM
    41471 1pbb:A (2.5) BS01 FAD 1.14.13.2 GO:0016491 ... P00438 7520279
    41472 1pbb:A (2.5) BS02 DOB 1.14.13.2 GO:0016491 ... P00438 7520279
    41473 1pbc:A (2.8) BS01 FAD 1.14.13.2 GO:0016491 ... P00438 7520279
    41474 1pbc:A (2.8) BS02 BHA 1.14.13.2 GO:0016491 ... P00438 7520279
    41475 1pbd:A (2.3) BS01 FAD 1.14.13.2 GO:0016491 ... P00438 7520279
    41476 1pbd:A (2.3) BS02 PAB 1.14.13.2 GO:0016491 ... P00438 7520279
    41477 1pbe:A (1.9) BS01 FAD 1.14.13.2 GO:0016491 ... P00438 2553983
    41478 1pbf:A (2.7) BS01 FAD 1.14.13.2 GO:0016491 ... P00438 7520279
    41479 1pbf:A (2.7) BS02 BHA 1.14.13.2 GO:0016491 ... P00438 7520279
    41480 1pbk:A (2.5) BS01 RAP 5.2.1.8 GO:0003755 ... Q00688 N/A MOAD: Ki=0.9nM
    41481 1pbo:A (2.2) BS01 SES ? GO:0005549 ... P07435 8901871
    41482 1pbo:B (2.2) BS01 SES ? GO:0005549 ... P07435 8901871
    41483 1pbp:A (1.9) BS01 PO4 ? GO:0006817 ... P0AG82 7929197
    41484 1pbq:A (1.9) BS01 DK1 ? GO:0015276 ... P35439 12805203 MOAD: Ki=0.54uM
    BindingDB: Ki=40nM, EC50=330nM, IC50=860nM
    41485 1pbq:B (1.9) BS01 DK1 ? GO:0015276 ... P35439 12805203 MOAD: Ki=0.54uM
    BindingDB: Ki=40nM, EC50=330nM, IC50=860nM
    41486 1pbx:A (2.5) BS01 HEM ? GO:0004601 ... P80043 1560461
    41487 1pbx:B (2.5) BS01 HEM ? GO:0004601 ... P80044 1560461
    41488 1pby:A (1.7) BS01 HEC 1.4.99.3 GO:0009055 ... Q8VUT0 12925784
    41489 1pby:A (1.7) BS02 HEC 1.4.99.3 GO:0009055 ... Q8VUT0 12925784
    41490 1pby:B (1.7) BS01 HEC ? N/A Q8VUS7 12925784
    41491 1pc3:A (2.16) BS01 PO4 ? GO:0005515 ... P9WGU1 12842040
    41492 1pc3:B (2.16) BS01 PO4 ? GO:0005515 ... P9WGU1 12842040
    41493 1pc4:A (1.65) BS01 SF4 ? GO:0009055 ... P00214 12962482
    41494 1pc4:A (1.65) BS02 F3S ? GO:0009055 ... P00214 12962482
    41495 1pc5:A (1.8) BS01 SF4 ? GO:0009055 ... P00214 12962482
    41496 1pc5:A (1.8) BS02 F3S ? GO:0009055 ... P00214 12962482
    41497 1pca:A (2.0) BS01 ZN 3.4.17.1 GO:0004181 ... P09954 1548696
    41498 1pca:A (2.0) BS02 VAL 3.4.17.1 GO:0004181 ... P09954 1548696
    41499 1pcg:A (2.7) BS01 peptide ? N/A P03372 13679575
    41500 1pcg:A (2.7) BS02 EST ? N/A P03372 13679575 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    41501 1pcg:B (2.7) BS01 peptide ? N/A P03372 13679575
    41502 1pcg:B (2.7) BS02 EST ? N/A P03372 13679575 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    41503 1pcj:X (2.0) BS01 M1P 5.4.2.2
    5.4.2.8
    GO:0000287 ... P26276 14725765
    41504 1pcj:X (2.0) BS02 ZN 5.4.2.2
    5.4.2.8
    GO:0000287 ... P26276 14725765
    41505 1pck:A (1.8) BS01 PEZ 2.5.1.55 GO:0005737 ... O66496 14675946
    41506 1pck:B (1.8) BS01 PEZ 2.5.1.55 GO:0005737 ... O66496 14675946
    41507 1pcm:X (1.9) BS01 ZN 5.4.2.2
    5.4.2.8
    GO:0000287 ... P26276 14725765
    41508 1pcm:X (1.9) BS02 M6P 5.4.2.2
    5.4.2.8
    GO:0000287 ... P26276 14725765
    41509 1pcq:A (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41510 1pcq:A (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41511 1pcq:B (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41512 1pcq:B (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41513 1pcq:C (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41514 1pcq:C (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41515 1pcq:D (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41516 1pcq:D (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41517 1pcq:E (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41518 1pcq:E (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41519 1pcq:F (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41520 1pcq:F (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41521 1pcq:G (2.808) BS01 ADP 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41522 1pcq:G (2.808) BS02 AF3 5.6.1.7 GO:0000287 ... P0A6F5 14517228
    41523 1pcr:L (2.65) BS01 BCL ? GO:0009772 ... P0C0Y8 7866744
    41524 1pcr:L (2.65) BS02 BCL ? GO:0009772 ... P0C0Y8 7866744
    41525 1pcr:L (2.65) BS03 BCL ? GO:0009772 ... P0C0Y8 7866744
    41526 1pcr:L (2.65) BS04 BPH ? GO:0009772 ... P0C0Y8 7866744
    41527 1pcr:L (2.65) BS05 U10 ? GO:0009772 ... P0C0Y8 7866744
    41528 1pcr:L (2.65) BS06 FE ? GO:0009772 ... P0C0Y8 7866744
    41529 1pcr:L (2.65) BS07 BPH ? GO:0009772 ... P0C0Y8 7866744
    41530 1pcr:M (2.65) BS01 BCL ? GO:0009772 ... P0C0Y9 7866744
    41531 1pcr:M (2.65) BS02 BCL ? GO:0009772 ... P0C0Y9 7866744
    41532 1pcr:M (2.65) BS03 BPH ? GO:0009772 ... P0C0Y9 7866744
    41533 1pcr:M (2.65) BS04 FE ? GO:0009772 ... P0C0Y9 7866744
    41534 1pcr:M (2.65) BS05 BCL ? GO:0009772 ... P0C0Y9 7866744
    41535 1pcr:M (2.65) BS06 BPH ? GO:0009772 ... P0C0Y9 7866744
    41536 1pcr:M (2.65) BS07 U10 ? GO:0009772 ... P0C0Y9 7866744
    41537 1pcr:M (2.65) BS08 SPO ? GO:0009772 ... P0C0Y9 7866744
    41538 1pcs:A (2.15) BS01 CU ? GO:0005507 ... P21697 9466912
    41539 1pcw:A (1.85) BS01 H4P 2.5.1.55 GO:0005737 ... O66496 14675946
    41540 1pcw:B (1.85) BS01 H4P 2.5.1.55 GO:0005737 ... O66496 14675946
    41541 1pcx:A (2.5) BS01 peptide ? GO:0006886 ... P40482 12941276
    41542 1pcx:A (2.5) BS02 ZN ? GO:0006886 ... P40482 12941276
    41543 1pd0:A (2.6) BS01 peptide ? GO:0006886 ... P40482 12941276
    41544 1pd0:A (2.6) BS02 ZN ? GO:0006886 ... P40482 12941276
    41545 1pd1:A (2.6) BS01 peptide ? GO:0006886 ... P40482 12941276
    41546 1pd1:A (2.6) BS02 ZN ? GO:0006886 ... P40482 12941276
    41547 1pd2:1 (2.3) BS01 GSH 2.5.1.18
    5.3.99.2
    GO:0000287 ... O35543 9323136
    41548 1pd2:2 (2.3) BS01 GSH 2.5.1.18
    5.3.99.2
    GO:0000287 ... O35543 9323136
    41549 1pd7:A (-1.00) BS01 peptide ? GO:0003714 ... Q62141 14705930
    41550 1pd8:A (2.1) BS01 NDP 1.5.1.3 GO:0000900 ... P00374 12925791
    41551 1pd8:A (2.1) BS02 CO4 1.5.1.3 GO:0000900 ... P00374 12925791
    41552 1pd9:A (2.2) BS01 CO4 1.5.1.3 GO:0000900 ... P00374 12925791
    41553 1pda:A (1.76) BS01 DPM 2.5.1.61 GO:0004418 ... P06983 1522882
    41554 1pdh:A (2.1) BS01 FAS 1.14.13.2 GO:0016491 ... P00438 7756982
    41555 1pdn:C (2.5) BS01 dna ? GO:0003677 ... P06601 7867071
    41556 1pdn:C (2.5) BS02 dna ? GO:0003677 ... P06601 7867071
    41557 1pdq:A (1.76) BS01 peptide ? N/A P26017 12897054
    41558 1pdx:A (-1.00) BS01 FES ? GO:0005515 ... P00259 10200155
    41559 1pdz:A (2.2) BS01 PGA 4.2.1.11 GO:0000015 ... P56252 7547999 MOAD: Ki=0.2mM
    41560 1pdz:A (2.2) BS02 MN 4.2.1.11 GO:0000015 ... P56252 7547999
    41561 1pe1:A (1.74) BS01 2PG 2.5.1.55 GO:0005737 ... O66496 14675946
    41562 1pe1:B (1.74) BS01 2PG 2.5.1.55 GO:0005737 ... O66496 14675946
    41563 1pe5:A (1.7) BS01 ZN 3.4.24.27 GO:0004222 ... P00800 N/A
    41564 1pe5:A (1.7) BS02 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41565 1pe5:A (1.7) BS03 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41566 1pe5:A (1.7) BS04 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41567 1pe5:A (1.7) BS05 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41568 1pe5:A (1.7) BS06 BR3 3.4.24.27 GO:0004222 ... P00800 N/A
    41569 1pe5:A (1.7) BS07 LEU 3.4.24.27 GO:0004222 ... P00800 N/A
    41570 1pe5:A (1.7) BS08 LEN 3.4.24.27 GO:0004222 ... P00800 N/A
    41571 1pe6:A (2.1) BS01 E6C 3.4.22.2 GO:0006508 ... P00784 1860874
    41572 1pe7:A (1.82) BS01 ZN 3.4.24.27 GO:0004222 ... P00800 N/A
    41573 1pe7:A (1.82) BS02 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41574 1pe7:A (1.82) BS03 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41575 1pe7:A (1.82) BS04 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41576 1pe7:A (1.82) BS05 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41577 1pe7:A (1.82) BS06 4BR 3.4.24.27 GO:0004222 ... P00800 N/A
    41578 1pe7:A (1.82) BS07 LEU 3.4.24.27 GO:0004222 ... P00800 N/A
    41579 1pe7:A (1.82) BS08 LEN 3.4.24.27 GO:0004222 ... P00800 N/A
    41580 1pe8:A (1.8) BS01 ZN 3.4.24.27 GO:0004222 ... P00800 N/A
    41581 1pe8:A (1.8) BS02 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41582 1pe8:A (1.8) BS03 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41583 1pe8:A (1.8) BS04 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41584 1pe8:A (1.8) BS05 CA 3.4.24.27 GO:0004222 ... P00800 N/A
    41585 1pe8:A (1.8) BS06 BR5 3.4.24.27 GO:0004222 ... P00800 N/A
    41586 1pe8:A (1.8) BS07 LEU 3.4.24.27 GO:0004222 ... P00800 N/A
    41587 1pea:A (2.1) BS01 ACM ? GO:0006865 ... P27017 7813419
    41588 1ped:A (2.15) BS01 ZN 1.1.1.80 GO:0008270 ... P25984 15299659
    41589 1ped:B (2.15) BS01 ZN 1.1.1.80 GO:0008270 ... P25984 15299659
    41590 1ped:C (2.15) BS01 ZN 1.1.1.80 GO:0008270 ... P25984 15299659
    41591 1ped:D (2.15) BS01 ZN 1.1.1.80 GO:0008270 ... P25984 15299659
    41592 1pee:A (1.5) BS01 HEM ? GO:0005576 ... Q26241 N/A
    41593 1peg:A (2.59) BS01 peptide 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41594 1peg:A (2.59) BS02 ZN 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41595 1peg:A (2.59) BS03 ZN 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41596 1peg:A (2.59) BS04 ZN 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41597 1peg:A (2.59) BS05 ZN 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41598 1peg:A (2.59) BS06 SAH 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41599 1peg:B (2.59) BS01 peptide 2.1.1.355 GO:0003690 ... Q8X225 12887903
    41600 1peg:B (2.59) BS02 ZN 2.1.1.355 GO:0003690 ... Q8X225 12887903

    Reference:
  • Chengxin Zhang, Xi Zhang, Lydia Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).