EvoDesign: de novo protein design based on structural and evolutionary profiles

Copy and paste the scaffold structure (Ca-only or full-atomic) in PDB format
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Or you can upload the PDB scaffold file:

Fold cutoff: TM-score > Explanation

Force field: Evolution-based only Evolution and Physics-based

Residue restrictions:

Model structure of designed sequences using I-TASSER: No Yes Explanation

E-mail: (required)

Protein Name: (optional)

Copy and paste the structure of the protein you want to design (full-atomic) in PDB format
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Or you can upload the PDB file of the protein you want to design:

Copy and paste the structure of the protein that your scaffold binds to (full-atomic) in PDB format
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Or you can upload the PDB file of the protein that your scaffold binds to:

Dock the two chains together: No Yes Explanation

Design Strategy: Redesign entire protein Redesign interface residues only Explanation

Fold cutoff: TM-score > Explanation

Residue restrictions:

Model structure of designed sequences using I-TASSER: No Yes Explanation

E-mail: (required)

Protein Name: (optional)

Copy and paste the complex structure of interest (full-atomic) in PDB format
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Or you can upload the PDB file of the complex:

Which chain should be designed: Chain 1 Chain 2

Fold cutoff: TM-score > Explanation

Residue restrictions:

Model structure of designed sequences using I-TASSER: No Yes Explanation

E-mail:

Protein Name: (optional)

Monomer Design