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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	CHEMBL2182055
Molecular formula	C25H23N3O2
IUPAC name	[(1R)-1-phenylethyl] N-[2-methyl-4-(4-phenylphenyl)pyrazol-3-yl]carbamate
Molecular weight	397.478
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.3
Synonyms	BDBM50398109 GMRXJBDWQJHRKY-GOSISDBHSA-N (4-Biphenyl-4-yl-2-methyl-2H-pyrazol-3-yl)-carbamic acid (R)-1-phenyl-ethyl ester SCHEMBL17083217
Inchi Key	GMRXJBDWQJHRKY-GOSISDBHSA-N
Inchi ID	InChI=1S/C25H23N3O2/c1-18(19-9-5-3-6-10-19)30-25(29)27-24-23(17-26-28(24)2)22-15-13-21(14-16-22)20-11-7-4-8-12-20/h3-18H,1-2H3,(H,27,29)/t18-/m1/s1
PubChem CID	71461123
ChEMBL	CHEMBL2182055
IUPHAR	N/A
BindingDB	50398109
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<30000.0 nM	PMID22894757	BindingDB,ChEMBL

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