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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Bos taurus (Bovine)
Gene	PTGER3
Synonym	PGE receptor EP3 subtype PGE2 receptor EP3 subtype Prostanoid EP3 receptor
Disease	N/A for non-human GPCRs
Length	417
Amino acid sequence	MKATRDHASAPFCTRFNHSDPGIWAAERAVEAPNNLTLPPEPSEDCGSVSVAFSMTMMITGFVGNALAITLVSKSYRRREGKRKKSFLLCIGWLALTDMVGQLLTSPVVIVLYLSHQRWEQLDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALATRAPHWYSSHMKTSVTRAVLLGVWLAVLAFALLPVLGVGQYTIQWPGTWCFISTGPGGNGTNSRQNWGNVFFASAFAILGLSALVVTFACNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNHTSVEHCKTYTENQDECNFFLIAVRLASLNQILDPWVYLLLRKILLQKFCQLLKGHSYGLDTEGGTENKDKEMKENLYISNLSRFFILLGHFTEARRGRGHIYLHTLEHQ
UniProt	P34979
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	8-iso Prostaglandin E1
Molecular formula	C20H34O5
IUPAC name	7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]heptanoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.2
Synonyms	119314-69-1 ACMC-20moau 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-keto-cyclopentyl]enanthic acid HMS3394L11 Prost-13-en-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,13E,15S)-, homopolymer (9CI) 11alpha,13E,15S]-11,15-Dihydroxy-9-oxoprosta-13-en-1-oic acid AN-10384 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid HMS3654H18 AC1L18QG SCHEMBL5303767 21003-46-3 CTK8F7408 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]heptanoic acid MCULE-5248179465 [ Show all ]
Inchi Key	GMVPRGQOIOIIMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)
PubChem CID	214
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.0 nM	PMID9694973	PDSP
Ki	4.0 nM	PMID9694973	PDSP

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