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GPCR

NameP2Y purinoceptor 12
SpeciesHomo sapiens (Human)
GeneP2RY12
SynonymP2Y12 platelet ADP receptor
P2Y12 receptor
P2YADP
purinergic receptor P2Y
P2Y12
[ Show all ]
DiseaseN/A
Length342
Amino acid sequenceMQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
UniProtQ9H244
Protein Data Bank4py0, 4pxz, 4ntj
GPCR-HGmod modelQ9H244
3D structure modelThis structure is from PDB ID 4py0.
BioLiPBL0272414,BL0272415, BL0276068, BL0276067, BL0276066, BL0272413
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2001
IUPHAR328
DrugBankBE0000110

Ligand

NameCHEMBL91359
Molecular formulaC15H17N3O3
IUPAC name7-(4-hydroxypentoxy)-1,3-dihydroimidazo[4,5-b]quinolin-2-one
Molecular weight287.319
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP1.6
SynonymsBDBM50000867
1,3-dihydro-7-(4-hydroxypentoxy)-2H-imidazo[4,5-b]-quinolin-2-one
SCHEMBL10656517
7-(4-Hydroxy-pentyloxy)-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
1,3-Dihydro-7-[(4-hydroxypentyl)oxy]-2H-imidazo[4,5-b]quinolin-2-one
[ Show all ]
Inchi KeyAOAQFGRPXBJZPI-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
PubChem CID14281041
ChEMBLCHEMBL91359
IUPHARN/A
BindingDB50000867
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMPMID1321910BindingDB,ChEMBL

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