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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	UNII-UGT5535REQ
Molecular formula	C17H18ClNO
IUPAC name	(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
Molecular weight	287.787
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.0
Synonyms	CAS_87134-87-0 NCGC00024877-01 r-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine Tocris-0925 (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol BDBM82247 NCGC00024877-04 SCH 23390 (R-enantiomer) ZINC2017838 2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (R)- BRD-K45435259-001-01-6 GOTMKOSCLKVOGG-OAHLLOKOSA-N PDSP2_000612 SCH23390 87075-17-0 CCG-204548 NCGC00024877-02 Sch 23388 UGT5535REQ 1H-3-Benzazepin-7-ol, 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-, (R)- Biomol-NT_000016 CHEMBL62 PDSP1_000615 SCH 23390,R(+) 8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SCH 23390) BRD-K45435259-003-03-8 Lopac0_000456 PDSP2_001507 SCHEMBL2916216 (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol AC1MI1XB CHEBI:92798 NCGC00024877-03 SCH 23390 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (R)- BPBio1_001173 CTK3F0072 PDSP1_001523 SCH-23390 [ Show all ]
Inchi Key	GOTMKOSCLKVOGG-OAHLLOKOSA-N
Inchi ID	InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
PubChem CID	3036864
ChEMBL	CHEMBL62
IUPHAR	N/A
BindingDB	82247
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID1971308, PMID2405158	BindingDB,ChEMBL
IC50	600.0 nM	PMID3172140	BindingDB,ChEMBL
IC50	1900.0 nM	PMID3172140	BindingDB,ChEMBL
Inhibition	53.0 %	PMID3039136	ChEMBL
K0.5	<500.0 nM	PMID7636869	ChEMBL
K0.5	600.0 nM	PMID8568818	ChEMBL
Ki	<1000.0 nM	PMID8863801	BindingDB,ChEMBL
Ki	0.537 nM	PMID10425088	ChEMBL
Ki	359.0 nM	PMID2905002	BindingDB
Ki	569.0 nM	PMID11044891	BindingDB
Ki	600.0 nM	PMID2966245	BindingDB,ChEMBL
Ki	648.0 nM	PMID2666667	BindingDB
Ki	648.0 nM	PMID2666667	ChEMBL
Ki	676.08 nM	PMID7996543	ChEMBL
Ki	760.0 nM	, PMID6387355, Bioorg. Med. Chem. Lett., (1992) 2:5:399	BindingDB,ChEMBL
Ki	820.0 nM	PMID2136916	BindingDB,ChEMBL
Ki	886.0 nM	PMID1833546	BindingDB,ChEMBL
Ki	895.0 nM	PMID2415793, PMID1397049, PMID7855175	BindingDB
Ki	900.0 nM	PMID3050089, PMID1397049	BindingDB,ChEMBL
Ki	2367.0 nM	PMID1356154	BindingDB
Ki	2500.0 nM	PMID2532362	BindingDB
Ki	3300.0 nM	PMID2532362	BindingDB
Ki	4650.0 nM	PMID8278895	BindingDB
Ki	5000.0 nM	PMID12023552	BindingDB
Ki	5560.0 nM	PMID1356154	BindingDB