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GPCR

NameSomatostatin receptor type 1
SpeciesRattus norvegicus (Rat)
GeneSstr1
SynonymSRIF-2
SS-1-R
SS1-R
SS1R
SST1 receptor
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
UniProtP28646
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4652
IUPHAR355
DrugBankN/A

Ligand

NameCHEMBL462157
Molecular formulaC28H31N5O3
IUPAC name3-[2-carbazol-9-ylethyl(methyl)amino]-1-[4-(4-nitrophenyl)piperazin-1-yl]propan-1-one
Molecular weight485.588
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.2
SynonymsN/A
Inchi KeyGRDUAFHKDVPDQM-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H31N5O3/c1-29(16-21-32-26-8-4-2-6-24(26)25-7-3-5-9-27(25)32)15-14-28(34)31-19-17-30(18-20-31)22-10-12-23(13-11-22)33(35)36/h2-13H,14-21H2,1H3
PubChem CID44564784
ChEMBLCHEMBL462157
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kd331.13 nMPMID19208473ChEMBL

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