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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H3 receptor
Species	Mus musculus (Mouse)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	P58406
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3263
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL2048413
Molecular formula	C17H27N5OS
IUPAC name	1-[5-(4-piperidin-1-ylpiperidin-1-yl)-1,3,4-thiadiazol-2-yl]piperidin-2-one
Molecular weight	349.497
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.4
Synonyms	BDBM50386361
Inchi Key	GTDIJQCEVHTETC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H27N5OS/c23-15-6-2-5-11-22(15)17-19-18-16(24-17)21-12-7-14(8-13-21)20-9-3-1-4-10-20/h14H,1-13H2
PubChem CID	62707525
ChEMBL	CHEMBL2048413
IUPHAR	N/A
BindingDB	50386361
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	120.0 nM	PMID24900450	BindingDB,ChEMBL

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