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GPCR

NameRelaxin receptor 2
SpeciesHomo sapiens (Human)
GeneRXFP2
SynonymRXFPR2
RXFP2
relaxin/insulin like family peptide receptor 2
relaxin receptor 2
Relaxin family peptide receptor 2
[ Show all ]
DiseaseN/A
Length754
Amino acid sequenceMIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProtQ8WXD0
Protein Data Bank2m96
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2m96.
BioLiPBL0278456
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1628482
IUPHARN/A
DrugBankN/A

Ligand

NameAC1MFEFV
Molecular formulaC20H16N2O6S2
IUPAC namemethyl 2-[4-hydroxy-3-(5-methylfuran-2-carbonyl)-5-oxo-2-thiophen-2-yl-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
Molecular weight444.476
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP4.0
SynonymsCHEMBL1389475
MolPort-000-481-651
459202-03-0
methyl 2-[3-hydroxy-4-(5-methyl-2-furoyl)-2-oxo-5-(2-thienyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
SR-01000245807
[ Show all ]
Inchi KeyGTOVRBJSKUYDAZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H16N2O6S2/c1-9-6-7-11(28-9)15(23)13-14(12-5-4-8-29-12)22(18(25)16(13)24)20-21-10(2)17(30-20)19(26)27-3/h4-8,14,24H,1-3H3
PubChem CID2917979
ChEMBLCHEMBL1389475
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency6897.0 nMPubChem BioAssay data setChEMBL

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