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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL1934125
Molecular formulaC28H29N3O2
IUPAC nameN-[(1S,2S)-1'-(9H-carbazol-3-ylmethyl)-2-hydroxyspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide
Molecular weight439.559
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP3.8
SynonymsBDBM50360706
Inchi KeyGTUCOPXBGYZNQP-RRPNLBNLSA-N
Inchi IDInChI=1S/C28H29N3O2/c1-18(32)29-26-21-7-2-4-8-23(21)28(27(26)33)12-14-31(15-13-28)17-19-10-11-25-22(16-19)20-6-3-5-9-24(20)30-25/h2-11,16,26-27,30,33H,12-15,17H2,1H3,(H,29,32)/t26-,27+/m0/s1
PubChem CID57400180
ChEMBLCHEMBL1934125
IUPHARN/A
BindingDB50360706
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC508.0 nMPMID22123324BindingDB,ChEMBL

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