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Name | Histamine H2 receptor |
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Species | Cavia porcellus (Guinea pig) |
Gene | HRH2 |
Synonym | Gastric receptor I H2R HH2R |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR |
UniProt | P47747 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2882 |
IUPHAR | N/A |
DrugBank | N/A |
Name | Rimcazole |
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Molecular formula | C21H27N3 |
IUPAC name | 9-[3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl]carbazole |
Molecular weight | 321.468 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 3.9 |
Synonyms | 9-[3-(3,5-cis-dimethylpiperazino)propyl]-carbazole 9-{3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl}-9H-carbazole BW 234U cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole (Rimcazole) (BW234U) [ Show all ] |
Inchi Key | GUDVQJXODNJRIJ-CALCHBBNSA-N |
Inchi ID | InChI=1S/C21H27N3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22H,7,12-15H2,1-2H3/t16-,17+ |
PubChem CID | 53389 |
ChEMBL | CHEMBL275707 |
IUPHAR | N/A |
BindingDB | 50019742 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
K0.5 | <5000.0 nM | PMID10447948 | ChEMBL |
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