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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL516801
Molecular formulaC29H31Cl2N3O2
IUPAC nameN-[[(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-(6-methoxypyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]methyl]acetamide
Molecular weight524.486
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP6.2
Synonyms(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(6-methoxypyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
BDBM50245891
Inchi KeyAOXJOMIDFAZSDN-SFTDATJTSA-N
Inchi IDInChI=1S/C29H31Cl2N3O2/c1-19(35)32-18-29(26-12-7-13-27(33-26)36-2)16-20-14-15-21(17-29)34(20)28(22-8-3-5-10-24(22)30)23-9-4-6-11-25(23)31/h3-13,20-21,28H,14-18H2,1-2H3,(H,32,35)/t20-,21-/m0/s1
PubChem CID44562704
ChEMBLN/A
IUPHARN/A
BindingDB50245891
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki4.0 nMPMID18990569BindingDB

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