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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL570074
Molecular formula	C15H22ClN3O2
IUPAC name	4-amino-5-chloro-N-(1-ethylpiperidin-4-yl)-2-methoxybenzamide
Molecular weight	311.81
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.8
Synonyms	4-amino-5-chloro-N-(1-ethylpiperidin-4-yl)-2-methoxybenzamide AC1Q3LTW BDBM50414679 AC1L2C4A
Inchi Key	APDRIMSIHRLFQL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22ClN3O2/c1-3-19-6-4-10(5-7-19)18-15(20)11-8-12(16)13(17)9-14(11)21-2/h8-10H,3-7,17H2,1-2H3,(H,18,20)
PubChem CID	44575
ChEMBL	CHEMBL570074
IUPHAR	N/A
BindingDB	50414679
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	79.43 nM	PMID19663444	BindingDB,ChEMBL
Intrinsic activity	<100.0 %	PMID19663444	ChEMBL
Ki	1000.0 nM	PMID19663444	BindingDB,ChEMBL

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