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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Somatostatin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Sstr2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	369
Amino acid sequence	MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30680
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2978
IUPHAR	356
DrugBank	N/A

Ligand

Name	CHEMBL440235
Molecular formula	C26H34N4O3
IUPAC name	6-[4-[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline-3-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one
Molecular weight	450.583
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.4
Synonyms	BDBM50423350
Inchi Key	HAFHOGWQDQXSBZ-KCZVDYSFSA-N
Inchi ID	InChI=1S/C26H34N4O3/c1-27-17-20(14-19-15-21-18(16-22(19)27)6-4-7-23(21)33-3)26(32)30-12-10-29(11-13-30)24-8-5-9-25(31)28(24)2/h4-9,19-20,22H,10-17H2,1-3H3/t19-,20-,22-/m1/s1
PubChem CID	44441875
ChEMBL	CHEMBL440235
IUPHAR	N/A
BindingDB	50423350
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	10964.8 nM	PMID17512199	ChEMBL
Kd	10965.0 nM	PMID17512199	BindingDB

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