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GPCR

NameCannabinoid receptor 2
SpeciesRattus norvegicus (Rat)
GeneCnr2
SynonymPeripheral cannabinoid receptor
CB2-R
CB2 receptor
CB2
CB-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProtQ9QZN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2470
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2381674
Molecular formulaC26H32N4O3
IUPAC nameN-(1-adamantyl)-2-(furan-2-yl)-7-oxo-4-pentylpyrazolo[1,5-a]pyrimidine-6-carboxamide
Molecular weight448.567
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.2
SynonymsN-(Adamantane-1-yl)-2-(2-furanyl)-4,7-dihydro-4-pentyl-7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamide
Inchi KeyHBXGMYPLVUUOLH-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H32N4O3/c1-2-3-4-7-29-16-20(25(32)30-23(29)12-21(28-30)22-6-5-8-33-22)24(31)27-26-13-17-9-18(14-26)11-19(10-17)15-26/h5-6,8,12,16-19H,2-4,7,9-11,13-15H2,1H3,(H,27,31)
PubChem CID71681350
ChEMBLCHEMBL2381674
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.14 nMPMID23697626ChEMBL

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