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Name | Beta-3 adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adrb3 |
Synonym | beta3-adrenoceptor beta3-adrenergic receptor Beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 400 |
Amino acid sequence | MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT |
UniProt | P26255 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4031 |
IUPHAR | 30 |
DrugBank | N/A |
Name | CHEMBL262265 |
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Molecular formula | C38H34ClF6NO7 |
IUPAC name | bis[2-[3-(trifluoromethyl)phenyl]ethyl] 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate |
Molecular weight | 766.13 |
Hydrogen bond acceptor | 14 |
Hydrogen bond donor | 2 |
XlogP | 9.0 |
Synonyms | 5-[(R)-2-[[(R)-beta-Hydroxy-3-chlorophenethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid bis[3-(trifluoromethyl)phenethyl] ester |
Inchi Key | HCFFAFGMNUZJPA-IPBJYNAHSA-N |
Inchi ID | InChI=1S/C38H34ClF6NO7/c1-23(46-22-31(47)27-7-4-10-30(39)21-27)17-26-11-12-32-33(20-26)53-36(52-32,34(48)50-15-13-24-5-2-8-28(18-24)37(40,41)42)35(49)51-16-14-25-6-3-9-29(19-25)38(43,44)45/h2-12,18-21,23,31,46-47H,13-17,22H2,1H3/t23-,31+/m1/s1 |
PubChem CID | 44300545 |
ChEMBL | CHEMBL262265 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Response | 28.0 % | PMID10450954 | ChEMBL |
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