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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 1
Species	Homo sapiens (Human)
Gene	CCR1
Synonym	macrophage inflammatory protein-1 alpha receptor MIP-1alpha-R MIP-1alpha/RANTES MIP-1alphaR MIP1aR RANTES-R Macrophage inflammatory protein 1-alpha receptor LD78 receptor HM145 C-C CKR-1 CC CKR1 CC-CKR-1 CCR-1 CCR1 CD191 CKR1 CMKBR1 [ Show all ]
Disease	Autoimmune diabetes Rheumatoid arthritis Chronic obstructive pulmonary disease
Length	355
Amino acid sequence	METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
UniProt	P32246
Protein Data Bank	N/A
GPCR-HGmod model	P32246
3D structure model	This predicted structure model is from GPCR-EXP P32246.
BioLiP	N/A
Therapeutic Target Database	T16016
ChEMBL	CHEMBL2413
IUPHAR	58
DrugBank	N/A

Ligand

Name	1,10-phenanthroline-4,7-dicarbaldehyde
Molecular formula	C14H8N2O2
IUPAC name	1,10-phenanthroline-4,7-dicarbaldehyde
Molecular weight	236.23
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	1.4
Synonyms	CHEMBL2205801 1,10-Phenanthroline-4,7-dicarboxaldehyde SCHEMBL1088410 BDBM50401343 J-400085 130897-87-9 ZINC95558531 PHOX11 [ Show all ]
Inchi Key	HCJOBZLFARGFLG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H8N2O2/c17-7-9-3-5-15-13-11(9)1-2-12-10(8-18)4-6-16-14(12)13/h1-8H
PubChem CID	14434082
ChEMBL	CHEMBL2205801
IUPHAR	N/A
BindingDB	50401343
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5000.0 nM	PMID22957890	BindingDB,ChEMBL
EC50	5011.87 nM	PMID22957890	BindingDB,ChEMBL
FC	4.5 -	PMID22957890	ChEMBL
IC50	<1000000.0 nM	PMID22957890	BindingDB,ChEMBL
IC50	>1000000.0 nM	PMID22957890	ChEMBL
Ratio EC50	1.2 -	PMID22957890	ChEMBL

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