You can:
Name | D(1A) dopamine receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Drd1 |
Synonym | D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 446 |
Amino acid sequence | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST |
UniProt | P18901 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL265 |
IUPHAR | 214 |
DrugBank | N/A |
Name | ISOCLOZAPINE |
---|---|
Molecular formula | C18H19ClN4 |
IUPAC name | 8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
Molecular weight | 326.828 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 3.1 |
Synonyms | 2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine BRN 0763655 MolPort-042-665-648 5H-DIBENZO(b,e)(1,4)DIAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)- CTK4E2258 [ Show all ] |
Inchi Key | APOMSSAGEAOUGO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
PubChem CID | 16104 |
ChEMBL | CHEMBL415300 |
IUPHAR | N/A |
BindingDB | 50010594 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 11.0 nM | PMID10377229, PMID9406603 | BindingDB,ChEMBL |
IC50 | 63.0 nM | PMID1967652, PMID2571728 | BindingDB,ChEMBL |
Ki | 14.0 nM | PMID8064797 | BindingDB,ChEMBL |
Ki | 28.0 nM | PMID7907148, PMID8101877 | BindingDB,ChEMBL |
Ki | 28.18 nM | PMID7907148 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218