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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL203445
Molecular formulaC28H31F4N5O
IUPAC name1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(4-methylpiperazin-1-yl)ethyl]urea
Molecular weight529.584
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP4.4
SynonymsBDBM50184916
N-[trans-5-(3-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N''-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[2-(4-methyl-1-piperazinyl)-ethyl]urea
SCHEMBL14265836
Inchi KeyHDFATZWMVJFIFI-DFZDUAMZSA-N
Inchi IDInChI=1S/C28H31F4N5O/c1-35-9-11-36(12-10-35)13-14-37(26(38)34-21-5-6-24(29)22(16-21)28(30,31)32)25-7-8-27(17-23(25)27)20-4-2-3-19(15-20)18-33/h2-6,15-16,23,25H,7-14,17H2,1H3,(H,34,38)/t23-,25-,27-/m1/s1
PubChem CID11526592
ChEMBLCHEMBL203445
IUPHARN/A
BindingDB50184916
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity53.0 %PMID16570926ChEMBL

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