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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

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GPCR

NameMetabotropic glutamate receptor 1
SpeciesRattus norvegicus (Rat)
GeneGrm1
SynonymmGluR1
SCAR13
mGlu1 receptor
metabotropic glutamate receptor 1
wobl
[ Show all ]
DiseaseN/A for non-human GPCRs
Length1199
Amino acid sequenceMVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
UniProtP23385
Protein Data Bank1iss, 1isr, 1ewk
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 1iss.
BioLiPBL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4477
IUPHAR289
DrugBankN/A

Ligand

NameCHEMBL278949
Molecular formulaC13H15NO5
IUPAC name4-amino-2,2-dimethyl-3H-chromene-4,7-dicarboxylic acid
Molecular weight265.265
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP-1.6
SynonymsBDBM50291679
4-amino-2,2-dimethyl-chroman-4,7-dicarboxylic Acid
Inchi KeyAADMYFPTDLOICR-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H15NO5/c1-12(2)6-13(14,11(17)18)8-4-3-7(10(15)16)5-9(8)19-12/h3-5H,6,14H2,1-2H3,(H,15,16)(H,17,18)
PubChem CID11777615
ChEMBLCHEMBL278949
IUPHARN/A
BindingDB50291679
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5093000.0 nM, Bioorg. Med. Chem. Lett., (1997) 7:9:1195BindingDB,ChEMBL

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