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GPCR

NameProstaglandin D2 receptor
SpeciesHomo sapiens (Human)
GenePTGDR
SynonymPGD2 receptor
DP1
DP1 receptor
PTGDR1
prostanoid DP receptor-like
[ Show all ]
DiseasePain
Dyslipidaemias
Rhinitis
Thromboembolism
Thrombosis
[ Show all ]
Length359
Amino acid sequenceMKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProtQ13258
Protein Data BankN/A
GPCR-HGmod modelQ13258
3D structure modelThis predicted structure model is from GPCR-EXP Q13258.
BioLiPN/A
Therapeutic Target DatabaseT68782
ChEMBLCHEMBL4427
IUPHAR338
DrugBankBE0000296

Ligand

NameCHEMBL1778505
Molecular formulaC23H24N2O3
IUPAC name2-[(7R)-7-[methyl-(2-phenylacetyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
Molecular weight376.456
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.0
SynonymsAPOZPXDYEILLTC-QGZVFWFLSA-N
(R)-2-(7-(N-methyl-2-phenylacetamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
BDBM50344168
SCHEMBL2188012
{(7R)-7-[methyl(phenylacetyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid
Inchi KeyAPOZPXDYEILLTC-QGZVFWFLSA-N
Inchi IDInChI=1S/C23H24N2O3/c1-24(22(26)13-16-7-3-2-4-8-16)17-11-12-21-19(14-23(27)28)18-9-5-6-10-20(18)25(21)15-17/h2-10,17H,11-15H2,1H3,(H,27,28)/t17-/m1/s1
PubChem CID54582728
ChEMBLCHEMBL1778505
IUPHARN/A
BindingDB50344168
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID21515053BindingDB,ChEMBL

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