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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesCavia porcellus (Guinea pig)
GeneCYSLTR1
SynonymCysLTR1
Cysteinyl leukotriene D4 receptor
LTD4 receptor
DiseaseN/A for non-human GPCRs
Length340
Amino acid sequenceMDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProtQ2NNR5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5645
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL15120
Molecular formulaC31H30ClN2O4S-
IUPAC name2-[[3-(2-carbamoylphenyl)-1-[3-[(7-chloroquinolin-2-yl)methoxy]phenyl]propyl]sulfanylmethyl]butanoate
Molecular weight562.101
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP7.1
SynonymsSodium; 2-{3-(2-carbamoyl-phenyl)-1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-propylsulfanylmethyl}-butyrate
BDBM50280686
Inchi KeyAPPLGAQTEJYNIL-UHFFFAOYSA-M
Inchi IDInChI=1S/C31H31ClN2O4S/c1-2-20(31(36)37)19-39-29(15-12-21-6-3-4-9-27(21)30(33)35)23-7-5-8-26(16-23)38-18-25-14-11-22-10-13-24(32)17-28(22)34-25/h3-11,13-14,16-17,20,29H,2,12,15,18-19H2,1H3,(H2,33,35)(H,36,37)/p-1
PubChem CID91934666
ChEMBLN/A
IUPHARN/A
BindingDB50280686
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC500.47 nMN/ABindingDB

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