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Name | Platelet-activating factor receptor |
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Species | Homo sapiens (Human) |
Gene | PTAFR |
Synonym | PAFr PAF-R PAF receptor AGEPC receptor |
Disease | Nerve injury Ocular allergy Pain Unspecified Psoriasis [ Show all ] |
Length | 342 |
Amino acid sequence | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN |
UniProt | P25105 |
Protein Data Bank | 5zkq, 5zkp |
GPCR-HGmod model | P25105 |
3D structure model | This structure is from PDB ID 5zkq. |
BioLiP | BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414 |
Therapeutic Target Database | T87023 |
ChEMBL | CHEMBL250 |
IUPHAR | 334 |
DrugBank | BE0005561 |
Name | CHEMBL160290 |
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Molecular formula | C28H40N2O8 |
IUPAC name | 1-butan-2-yl-1-hydroxy-3-[3-methoxy-2-propoxy-5-[5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]urea |
Molecular weight | 532.634 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 4.4 |
Synonyms | BDBM50286661 N-hydroxy-N''-[3-methoxy-5-(5-(3,4,5-trimethoxyphenyl)tetrathydrofuran-2-yl)-2-propoxyphenyl]-N-(sec-butyl)-N-hydroxyurea |
Inchi Key | APPWRAFBZLNNIZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H40N2O8/c1-8-12-37-26-20(29-28(31)30(32)17(3)9-2)13-18(14-23(26)33-4)21-10-11-22(38-21)19-15-24(34-5)27(36-7)25(16-19)35-6/h13-17,21-22,32H,8-12H2,1-7H3,(H,29,31) |
PubChem CID | 44372435 |
ChEMBL | CHEMBL160290 |
IUPHAR | N/A |
BindingDB | 50286661 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 25.0 nM | , Bioorg. Med. Chem. Lett., (1995) 5:6:643 | BindingDB,ChEMBL |
IC50 | 1606.0 nM | , Bioorg. Med. Chem. Lett., (1995) 5:6:643 | BindingDB,ChEMBL |
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