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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL1078960
Molecular formula	C24H28N4O3S
IUPAC name	1-[4-[[4-(2-amino-2-methylpropyl)phenyl]sulfamoyl]phenyl]-3-(4-methylphenyl)urea
Molecular weight	452.573
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	3.3
Synonyms	BDBM50311115 N-(4-(2-amino-2-methylpropyl)phenyl)-4-(3-p-tolylureido)benzenesulfonamide
Inchi Key	APRNMJWYFKJVAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28N4O3S/c1-17-4-8-19(9-5-17)26-23(29)27-20-12-14-22(15-13-20)32(30,31)28-21-10-6-18(7-11-21)16-24(2,3)25/h4-15,28H,16,25H2,1-3H3,(H2,26,27,29)
PubChem CID	46882270
ChEMBL	CHEMBL1078960
IUPHAR	N/A
BindingDB	50311115
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	3.0 %	PMID19767208	ChEMBL
IC50	77.0 nM	PMID19767208	BindingDB,ChEMBL

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