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Name | 5-hydroxytryptamine receptor 1D |
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Species | Sus scrofa (Pig) |
Gene | HTR1D |
Synonym | 5-HT-1D 5-HT1D Serotonin receptor 1D |
Disease | N/A for non-human GPCRs |
Length | 291 |
Amino acid sequence | AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV |
UniProt | P79400 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4105 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL62902 |
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Molecular formula | C26H21F3N4S |
IUPAC name | 3-phenyl-8-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene |
Molecular weight | 478.537 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 7.4 |
Synonyms | BDBM50407758 SCHEMBL7303643 |
Inchi Key | HEUZTEKWBIBQQP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H21F3N4S/c27-26(28,29)19-8-4-9-20(16-19)31-12-14-32(15-13-31)24-22-10-5-11-33(22)23-21(17-34-25(23)30-24)18-6-2-1-3-7-18/h1-11,16-17H,12-15H2 |
PubChem CID | 10576618 |
ChEMBL | CHEMBL62902 |
IUPHAR | N/A |
BindingDB | 50407758 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 35481.3 nM | PMID8642566 | BindingDB,ChEMBL |
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