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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	Bufotenium
Molecular formula	C13H19N2O+
IUPAC name	2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethylazanium
Molecular weight	219.308
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.2
Synonyms	2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethyl-ammonium BDBM50130280 N,N,N-Trimethylserotonin 5-Hydroxy-N,N,N-trimethyl-1H-indole-3-ethanaminium C13664 AC1LCVFT CHEMBL317971 2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethylazanium Bufoteninium PDSP1_001578 CHEBI:31879 1H-Indole-3-ethanaminium, 5-hydroxy-N,N,N-trimethyl- B3361[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-trimethyl-ammonium DTXSID90209469 5-HTQ PDSP2_001562 60657-23-0 [ Show all ]
Inchi Key	HIYGARYIJIZXGW-UHFFFAOYSA-O
Inchi ID	InChI=1S/C13H18N2O/c1-15(2,3)7-6-10-9-14-13-5-4-11(16)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3/p+1
PubChem CID	656705
ChEMBL	CHEMBL317971
IUPHAR	N/A
BindingDB	50130280
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9225298	BindingDB

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