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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL606393
Molecular formulaC30H31FN2O4
IUPAC name3-[4-[(3-cyanophenoxy)methyl]-2-[[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]carbamoyl]phenyl]propanoic acid
Molecular weight502.586
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP5.8
SynonymsSCHEMBL2982812
3-[4-[(3-Cyanophenoxy)methyl]-2-({[1-(4-fluoro-3-methylphenyl)-3-methylbutyl]amino}carbonyl)phenyl]propanoic acid
BDBM50307447
Inchi KeyAQFQEYKSALVFDX-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H31FN2O4/c1-19(2)13-28(24-9-11-27(31)20(3)14-24)33-30(36)26-16-22(7-8-23(26)10-12-29(34)35)18-37-25-6-4-5-21(15-25)17-32/h4-9,11,14-16,19,28H,10,12-13,18H2,1-3H3,(H,33,36)(H,34,35)
PubChem CID23017462
ChEMBLCHEMBL606393
IUPHARN/A
BindingDB50307447
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC502.8 nMPMID20129791BindingDB,ChEMBL
Ki0.2 nMPMID20129791BindingDB,ChEMBL

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