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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesHomo sapiens (Human)
GeneHTR1D
SynonymSerotonin 1D alpha receptor
serotonin receptor 1D
HTRL
Htr1db
5-HT-1D
[ Show all ]
DiseaseAcute migraine
Epilepsy
Migraine headaches
Mood disorder
Migraine
[ Show all ]
Length377
Amino acid sequenceMSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProtP28221
Protein Data BankN/A
GPCR-HGmod modelP28221
3D structure modelThis predicted structure model is from GPCR-EXP P28221.
BioLiPN/A
Therapeutic Target DatabaseT11072
ChEMBLCHEMBL1983
IUPHAR3
DrugBankBE0000659

Ligand

Namepropranolol
Molecular formulaC16H21NO2
IUPAC name1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular weight259.349
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.0
Synonyms2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-
etalong
Propranalol
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
HMS3428G03
[ Show all ]
Inchi KeyAQHHHDLHHXJYJD-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PubChem CID4946
ChEMBLCHEMBL27
IUPHAR564
BindingDB25761
DrugBankDB00571

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3700.0 nMPeroutka et al., PMID1989PDSP
Ki5500.0 nMWaeber et al., PMID1988PDSP

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