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GPCR

NameBeta-3 adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRB3
SynonymADRB
Adrb-3
adrenergic receptor
atypical beta-adrenoceptor
beta 3-AR
[ Show all ]
DiseaseUrinary incontinence
Diabetes
Glaucoma
Hypertension
Irritable bowel syndrome
[ Show all ]
Length408
Amino acid sequenceMAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProtP13945
Protein Data BankN/A
GPCR-HGmod modelP13945
3D structure modelThis predicted structure model is from GPCR-EXP P13945.
BioLiPN/A
Therapeutic Target DatabaseT51408
ChEMBLCHEMBL246
IUPHAR30
DrugBankBE0001012, BE0004872

Ligand

NameCHEMBL321957
Molecular formulaC28H36N4O5S
IUPAC namehexyl N-[4-[[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]sulfamoyl]phenyl]carbamate
Molecular weight540.679
Hydrogen bond acceptor8
Hydrogen bond donor4
XlogP4.0
Synonyms(4-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenylsulfamoyl}-phenyl)-carbamic acid hexyl ester
BDBM50072379
Inchi KeyAQJAFHZELYBXMJ-MHZLTWQESA-N
Inchi IDInChI=1S/C28H36N4O5S/c1-2-3-4-5-19-37-28(34)31-24-12-14-26(15-13-24)38(35,36)32-25-10-8-22(9-11-25)16-18-30-21-27(33)23-7-6-17-29-20-23/h6-15,17,20,27,30,32-33H,2-5,16,18-19,21H2,1H3,(H,31,34)/t27-/m0/s1
PubChem CID44335589
ChEMBLCHEMBL321957
IUPHARN/A
BindingDB50072379
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activation70.0 %PMID9873681ChEMBL
EC5027.0 nMPMID9873681BindingDB,ChEMBL

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