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Name | Histamine H1 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Hrh1 |
Synonym | H1 receptor H1R HH1R Hisr |
Disease | N/A for non-human GPCRs |
Length | 486 |
Amino acid sequence | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS |
UniProt | P31390 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4701 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL15986 |
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Molecular formula | C23H28N2OS |
IUPAC name | 3-methyl-6-[4-(4-phenylpiperidin-1-yl)butyl]-1,3-benzothiazol-2-one |
Molecular weight | 380.55 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 5.1 |
Synonyms | 3-Methyl-6-[4-(4-phenyl-piperidin-1-yl)-butyl]-3H-benzothiazol-2-one BDBM50111632 SCHEMBL8117008 3-Methyl-6-[4-(4-phenylpiperidino)butyl]benzothiazoline-2-one |
Inchi Key | HNSXISBJVADGBQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H28N2OS/c1-24-21-11-10-18(17-22(21)27-23(24)26)7-5-6-14-25-15-12-20(13-16-25)19-8-3-2-4-9-19/h2-4,8-11,17,20H,5-7,12-16H2,1H3 |
PubChem CID | 10339767 |
ChEMBL | CHEMBL15986 |
IUPHAR | N/A |
BindingDB | 50111632 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 6000.0 nM | PMID11934576 | BindingDB,ChEMBL |
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