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Name | Histamine H2 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH2 |
Synonym | HH2R H2R Gastric receptor I H2 receptor |
Disease | Ulcerative colitis Pain Peptic ulcer Gastroesophageal reflux disease Gastric ulcer [ Show all ] |
Length | 359 |
Amino acid sequence | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR |
UniProt | P25021 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25021 |
3D structure model | This predicted structure model is from GPCR-EXP P25021. |
BioLiP | N/A |
Therapeutic Target Database | T30985 |
ChEMBL | CHEMBL1941 |
IUPHAR | 263 |
DrugBank | BE0000112 |
Name | CHEMBL483400 |
---|---|
Molecular formula | C24H26FN3O2 |
IUPAC name | 3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-5-fluoro-2-methylquinazolin-4-one |
Molecular weight | 407.489 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 4.0 |
Synonyms | 3-(4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl)-5-fluoro-2-methyl-4(3H)-quinazolinone BDBM50274692 SCHEMBL502064 |
Inchi Key | HOYKNPXNYUOCRM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H26FN3O2/c1-16-26-22-7-3-6-21(25)23(22)24(29)28(16)18-8-10-19(11-9-18)30-20-12-14-27(15-13-20)17-4-2-5-17/h3,6-11,17,20H,2,4-5,12-15H2,1H3 |
PubChem CID | 23151209 |
ChEMBL | CHEMBL483400 |
IUPHAR | N/A |
BindingDB | 50274692 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID18841880 | BindingDB,ChEMBL |
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