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GPCR

NameG-protein coupled receptor 4
SpeciesHomo sapiens (Human)
GeneGPR4
SynonymG-protein coupled receptor 19
GPR19
GPR4
DiseaseN/A
Length362
Amino acid sequenceMGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProtP46093
Protein Data BankN/A
GPCR-HGmod modelP46093
3D structure modelThis predicted structure model is from GPCR-EXP P46093.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3638324
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3675739
Molecular formulaC26H33N7
IUPAC name1-[[1-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]pyrazol-4-yl]methyl]piperidin-4-amine
Molecular weight443.599
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.3
SynonymsUS8748435, 30
BDBM123505
SCHEMBL12802702
Inchi KeyAQXAHWJITJTGRT-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H33N7/c1-4-25-24(26-29-18(2)13-19(3)33(26)30-25)14-20-5-7-23(8-6-20)32-17-21(15-28-32)16-31-11-9-22(27)10-12-31/h5-8,13,15,17,22H,4,9-12,14,16,27H2,1-3H3
PubChem CID68379190
ChEMBLCHEMBL3675739
IUPHARN/A
BindingDB123505
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5026.0 nM, NoneBindingDB,ChEMBL

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