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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameCHEMBL131476
Molecular formulaC20H27N3O2
IUPAC name3-(1H-imidazol-5-yl)propyl N-[cyclohexyl(phenyl)methyl]carbamate
Molecular weight341.455
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.3
SynonymsBDBM50118153
(Cyclohexyl-phenyl-methyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester;C2H2O4
Inchi KeyHRBGUFPRCCRUJW-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H27N3O2/c24-20(25-13-7-12-18-14-21-15-22-18)23-19(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1,3-4,8-9,14-15,17,19H,2,5-7,10-13H2,(H,21,22)(H,23,24)
PubChem CID11089134
ChEMBLCHEMBL131476
IUPHARN/A
BindingDB50118153
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED5015.0 mg.kg-1PMID12190321ChEMBL

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