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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL131476
Molecular formula	C20H27N3O2
IUPAC name	3-(1H-imidazol-5-yl)propyl N-[cyclohexyl(phenyl)methyl]carbamate
Molecular weight	341.455
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.3
Synonyms	BDBM50118153 (Cyclohexyl-phenyl-methyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester;C2H2O4
Inchi Key	HRBGUFPRCCRUJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H27N3O2/c24-20(25-13-7-12-18-14-21-15-22-18)23-19(16-8-3-1-4-9-16)17-10-5-2-6-11-17/h1,3-4,8-9,14-15,17,19H,2,5-7,10-13H2,(H,21,22)(H,23,24)
PubChem CID	11089134
ChEMBL	CHEMBL131476
IUPHAR	N/A
BindingDB	50118153
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	7943.28 nM	PMID12190321	BindingDB,ChEMBL

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