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Name | Alpha-1A adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA1A |
Synonym | alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c [ Show all ] |
Disease | Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma [ Show all ] |
Length | 466 |
Amino acid sequence | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV |
UniProt | P35348 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35348 |
3D structure model | This predicted structure model is from GPCR-EXP P35348. |
BioLiP | N/A |
Therapeutic Target Database | T92609 |
ChEMBL | CHEMBL229 |
IUPHAR | 22 |
DrugBank | BE0000501 |
Name | naftopidil |
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Molecular formula | C24H28N2O3 |
IUPAC name | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol |
Molecular weight | 392.499 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.1 |
Synonyms | O220 Avishot SAM001246658 BRD-A01787639-300-03-7 ST50794017 [ Show all ] |
Inchi Key | HRRBJVNMSRJFHQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3 |
PubChem CID | 4418 |
ChEMBL | CHEMBL142635 |
IUPHAR | N/A |
BindingDB | 50773 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 555.0 nM | PMID26643219 | ChEMBL |
Ki | 3.7 nM | PMID15664832 | BindingDB,ChEMBL |
Ki | 5.88 nM | Med Chem Res, (2011) 20:9:1455 | ChEMBL |
Ki | 5.888 nM | Med Chem Res, (2011) 20:9:1455 | ChEMBL |
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