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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL540132
Molecular formulaC42H65ClN6O4+2
IUPAC name2-[3-[[6-[2-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)hydrazinyl]-6-oxohexyl]carbamoyl]-5-[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium
Molecular weight753.47
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP7.8
SynonymsBDBM50371199
CHEMBL1190117
Inchi KeyHSAIXSYFGMGWPJ-UHFFFAOYSA-P
Inchi IDInChI=1S/C42H63ClN6O4/c1-7-48(8-2,9-3)24-26-52-34-28-32(29-35(31-34)53-27-25-49(10-4,11-5)12-6)42(51)44-23-17-13-14-20-40(50)46-47-41-36-18-15-16-19-38(36)45-39-30-33(43)21-22-37(39)41/h21-22,28-31H,7-20,23-27H2,1-6H3,(H-2,44,45,46,47,50,51)/p+2
PubChem CID23657687
ChEMBLN/A
IUPHARN/A
BindingDB50371199
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC501.5 nMPMID17944454BindingDB

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