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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS002249163
Molecular formulaC15H16N4O5S2
IUPAC name3-nitro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide
Molecular weight396.436
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP1.4
SynonymsZ31101881
3-nitro-4-[4-(2-thienylsulfonyl)piperazino]benzamide
HMS3067C16
MolPort-004-278-449
3-nitro-4-(4-thiophen-2-ylsulfonyl-1-piperazinyl)benzamide
[ Show all ]
Inchi KeyHTBGYCAMPKEQMQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H16N4O5S2/c16-15(20)11-3-4-12(13(10-11)19(21)22)17-5-7-18(8-6-17)26(23,24)14-2-1-9-25-14/h1-4,9-10H,5-8H2,(H2,16,20)
PubChem CID3932658
ChEMBLCHEMBL1709973
IUPHARN/A
BindingDB97168
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501089.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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