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Name | Neuropeptide Y receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | NPY1R |
Synonym | neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor [ Show all ] |
Disease | Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder [ Show all ] |
Length | 384 |
Amino acid sequence | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI |
UniProt | P25929 |
Protein Data Bank | 5zbh |
GPCR-HGmod model | P25929 |
3D structure model | This structure is from PDB ID 5zbh. |
BioLiP | BL0411971 |
Therapeutic Target Database | T89213 |
ChEMBL | CHEMBL4777 |
IUPHAR | 305 |
DrugBank | N/A |
Name | CHEMBL585669 |
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Molecular formula | C22H27N5OS2 |
IUPAC name | 6-[(4,5-dimethyl-1,3-oxazol-2-yl)sulfanylmethyl]-N-[(6-methylpyridin-2-yl)methyl]-4-thiomorpholin-4-ylpyridin-2-amine |
Molecular weight | 441.612 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | BDBM50301204 6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-methylpyridin-2-yl)methyl)-4-thiomorpholinopyridin-2-amine |
Inchi Key | ARDIAMNHXOVJPO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H27N5OS2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-29-10-8-27)11-19(26-21)14-30-22-25-16(2)17(3)28-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26) |
PubChem CID | 45487490 |
ChEMBL | CHEMBL585669 |
IUPHAR | N/A |
BindingDB | 50301204 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 0.16 nM | PMID19640706 | BindingDB,ChEMBL |
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