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GPCR

NameKiSS-1 receptor
SpeciesHomo sapiens (Human)
GeneKISS1R
SynonymMetastin receptor
Kisspeptins receptor
kisspeptin receptor
KiSS1-derived peptide receptor
KiSS-1R
[ Show all ]
DiseaseProstate cancer
Length398
Amino acid sequenceMHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
UniProtQ969F8
Protein Data BankN/A
GPCR-HGmod modelQ969F8
3D structure modelThis predicted structure model is from GPCR-EXP Q969F8.
BioLiPN/A
Therapeutic Target DatabaseT39123
ChEMBLCHEMBL5413
IUPHAR266
DrugBankN/A

Ligand

NameCHEMBL2152066
Molecular formulaC60H77N15O14
IUPAC name(2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-3-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide
Molecular weight1232.37
Hydrogen bond acceptor16
Hydrogen bond donor17
XlogP-2.1
SynonymsBDBM50392496
Inchi KeyHTIXSPCSTQKIDF-XCLFSWKQSA-N
Inchi IDInChI=1S/C60H77N15O14/c1-32(2)21-42(55(84)74-47(28-61)59(88)69-41(52(65)81)23-33-11-5-3-6-12-33)68-51(80)30-67-54(83)43(24-34-13-7-4-8-14-34)71-60(89)48(31-76)75-58(87)46(27-50(64)79)73-56(85)44(25-36-29-66-40-16-10-9-15-38(36)40)72-57(86)45(26-49(63)78)70-53(82)39(62)22-35-17-19-37(77)20-18-35/h3-20,29,32,39,41-48,66,76-77H,21-28,30-31,61-62H2,1-2H3,(H2,63,78)(H2,64,79)(H2,65,81)(H,67,83)(H,68,80)(H,69,88)(H,70,82)(H,71,89)(H,72,86)(H,73,85)(H,74,84)(H,75,87)/t39-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
PubChem CID71460254
ChEMBLCHEMBL2152066
IUPHARN/A
BindingDB50392496
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501.4 nMPMID22995619BindingDB,ChEMBL
Ratio EC5021.0 -PMID22995619ChEMBL

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