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GPCR

NameG-protein coupled bile acid receptor 1
SpeciesMus musculus (Mouse)
GeneGpbar1
Synonymmembrane-type receptor for bile acids
M-BAR
hGPCR19
GPR131
GPCR19
[ Show all ]
DiseaseN/A for non-human GPCRs
Length329
Amino acid sequenceMMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAGLLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRVLRGRAKRDNPGPSTAYHTSSQCSIDLDLN
UniProtQ80SS6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1255150
IUPHAR37
DrugBankN/A

Ligand

NameCHEMBL1257611
Molecular formulaC23H21BrN2OS
IUPAC name2-(4-bromophenyl)-N-[(6-methoxy-2-thiophen-3-ylquinolin-3-yl)methyl]ethanamine
Molecular weight453.398
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.5
SynonymsBDBM50327539
SCHEMBL4880199
2-(4-bromophenyl)-n-((6-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
Inchi KeyARJPLMONKJULMK-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H21BrN2OS/c1-27-21-6-7-22-18(13-21)12-19(23(26-22)17-9-11-28-15-17)14-25-10-8-16-2-4-20(24)5-3-16/h2-7,9,11-13,15,25H,8,10,14H2,1H3
PubChem CID52942648
ChEMBLCHEMBL1257611
IUPHARN/A
BindingDB50327539
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID20801037BindingDB,ChEMBL

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