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GPCR

NameCannabinoid receptor 2
SpeciesRattus norvegicus (Rat)
GeneCnr2
SynonymPeripheral cannabinoid receptor
CB2-R
CB2 receptor
CB2
CB-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProtQ9QZN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2470
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL603736
Molecular formulaC19H28N2O4S
IUPAC name2,2-dimethyl-N-(7-morpholin-4-ylsulfonyl-2,3-dihydro-1H-inden-5-yl)butanamide
Molecular weight380.503
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.5
Synonyms2,2-dimethyl-N-(7-(morpholinosulfonyl)-2,3-dihydro-1H-inden-5-yl)butanamide
BDBM50304920
Inchi KeyHWFCLBPSZFIZHU-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H28N2O4S/c1-4-19(2,3)18(22)20-15-12-14-6-5-7-16(14)17(13-15)26(23,24)21-8-10-25-11-9-21/h12-13H,4-11H2,1-3H3,(H,20,22)
PubChem CID46224661
ChEMBLCHEMBL603736
IUPHARN/A
BindingDB50304920
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501700.0 nMPMID19919895BindingDB,ChEMBL

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