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GPCR

NameLutropin-choriogonadotropic hormone receptor
SpeciesRattus norvegicus (Rat)
GeneLhcgr
SynonymLuteinizing hormone receptor
LSH-R
LHR
LH/CG-R
LH-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length700
Amino acid sequenceMGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
UniProtP16235
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL429543
Molecular formulaC55H71N11O9
IUPAC name1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-3-hydroxy-2-[3-(1H-indol-3-yl)propanoylamino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-N-ethylpyrrolidine-2-carboxamide
Molecular weight1030.24
Hydrogen bond acceptor10
Hydrogen bond donor11
XlogP3.9
SynonymsBDBM50405786
Inchi KeyHYHJVZXAKUNAHS-LJXBCJFASA-N
Inchi IDInChI=1S/C55H71N11O9/c1-4-58-53(74)47-16-10-26-66(47)54(75)42(15-9-25-59-55(56)57)62-49(70)43(27-33(2)3)63-51(72)45(30-35-17-20-36-11-5-6-12-37(36)28-35)64-50(71)44(29-34-18-22-39(68)23-19-34)65-52(73)46(32-67)61-48(69)24-21-38-31-60-41-14-8-7-13-40(38)41/h5-8,11-14,17-20,22-23,28,31,33,42-47,60,67-68H,4,9-10,15-16,21,24-27,29-30,32H2,1-3H3,(H,58,74)(H,61,69)(H,62,70)(H,63,72)(H,64,71)(H,65,73)(H4,56,57,59)/t42-,43-,44-,45+,46-,47?/m0/s1
PubChem CID44314797
ChEMBLCHEMBL429543
IUPHARN/A
BindingDB50405786
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd25.12 nMPMID2552116BindingDB,ChEMBL
Ki1.698 nMPMID2552116ChEMBL

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