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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Somatostatin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Sstr2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	369
Amino acid sequence	MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30680
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2978
IUPHAR	356
DrugBank	N/A

Ligand

Name	CHEMBL250522
Molecular formula	C31H34N4O2
IUPAC name	8-[4-[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline-3-carbonyl]piperazin-1-yl]naphthalene-2-carbonitrile
Molecular weight	494.639
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.7
Synonyms	BDBM50423344
Inchi Key	IANUKZYEFHFNGQ-ITLAICGJSA-N
Inchi ID	InChI=1S/C31H34N4O2/c1-33-20-25(16-24-17-27-23(18-29(24)33)6-4-8-30(27)37-2)31(36)35-13-11-34(12-14-35)28-7-3-5-22-10-9-21(19-32)15-26(22)28/h3-10,15,24-25,29H,11-14,16-18,20H2,1-2H3/t24-,25-,29-/m1/s1
PubChem CID	44441877
ChEMBL	CHEMBL250522
IUPHAR	N/A
BindingDB	50423344
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	5248.0 nM	PMID17512199	BindingDB
Kd	5248.07 nM	PMID17512199	ChEMBL

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