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GPCR

NameMelanocortin receptor 3
SpeciesMus musculus (Mouse)
GeneMc3r
Synonymgamma-MSH receptor
MC3 receptor
MC3-R
melanocortin receptor 3
DiseaseN/A for non-human GPCRs
Length323
Amino acid sequenceMNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
UniProtP33033
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4774
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL61681
Molecular formulaC27H28N4O2
IUPAC name(2S)-2-(benzylcarbamoylamino)-3-(1H-indol-3-yl)-N-[(3-methylphenyl)methyl]propanamide
Molecular weight440.547
Hydrogen bond acceptor2
Hydrogen bond donor4
XlogP4.0
SynonymsBDBM50129183
2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(3-methyl-benzyl)-propionamide
Inchi KeyIBFSTESMBHZKAL-VWLOTQADSA-N
Inchi IDInChI=1S/C27H28N4O2/c1-19-8-7-11-21(14-19)17-29-26(32)25(15-22-18-28-24-13-6-5-12-23(22)24)31-27(33)30-16-20-9-3-2-4-10-20/h2-14,18,25,28H,15-17H2,1H3,(H,29,32)(H2,30,31,33)/t25-/m0/s1
PubChem CID44305815
ChEMBLCHEMBL61681
IUPHARN/A
BindingDB50129183
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<100000.0 nMPMID12781199BindingDB,ChEMBL

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