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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1202152
Molecular formulaC19H25Br2Cl2N3O
IUPAC name3-[4-[(E)-(2,6-dichlorophenyl)methoxyiminomethyl]pyridin-1-ium-1-yl]propyl-trimethylazanium;dibromide
Molecular weight542.137
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyARZDFCDMGLGYPJ-JYFUHLDJSA-L
Inchi IDInChI=1S/C19H25Cl2N3O.2BrH/c1-24(2,3)13-5-10-23-11-8-16(9-12-23)14-22-25-15-17-18(20)6-4-7-19(17)21;;/h4,6-9,11-12,14H,5,10,13,15H2,1-3H3;2*1H/q+2;;/p-2/b22-14+;;
PubChem CID10007509
ChEMBLCHEMBL1202152
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC5025000.0 nMPMID8182702ChEMBL
nH1.3 -PMID8182702ChEMBL
nH1.5 -PMID8182702ChEMBL

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