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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL452070
Molecular formula	C18H21N5O7S
IUPAC name	ethyl 1-[5-nitro-6-(4-sulfamoylphenoxy)pyrimidin-4-yl]piperidine-4-carboxylate
Molecular weight	451.454
Hydrogen bond acceptor	11
Hydrogen bond donor	1
XlogP	1.6
Synonyms	AB00009542-01 1-[5-Nitro-6-(4-sulfamoyl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester Oprea1_668957 AC1MWKEC BDBM50244539 Ethyl 1-[5-nitro-6-(4-sulfamoylphenoxy)pyrimidin-4-yl]piperidine-4-carboxylate [ Show all ]
Inchi Key	ARZIPPIZQPGTEA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H21N5O7S/c1-2-29-18(24)12-7-9-22(10-8-12)16-15(23(25)26)17(21-11-20-16)30-13-3-5-14(6-4-13)31(19,27)28/h3-6,11-12H,2,7-10H2,1H3,(H2,19,27,28)
PubChem CID	3800660
ChEMBL	CHEMBL452070
IUPHAR	N/A
BindingDB	50244539
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3000.0 nM	PMID18698756	BindingDB,ChEMBL

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