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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL2011832
Molecular formula	C33H38N4O4
IUPAC name	4-[(2R)-3-methyl-1-oxo-1-[4-[[(1R)-1-phenylethyl]amino]piperidin-1-yl]butan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
Molecular weight	554.691
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.8
Synonyms	BDBM50379322
Inchi Key	ARZUYFDFMKIKHV-SLGOVJDISA-N
Inchi ID	InChI=1S/C33H38N4O4/c1-22(2)31(33(40)36-18-16-25(17-19-36)34-23(3)24-10-6-4-7-11-24)37-21-30(38)35-29-15-14-27(20-28(29)32(37)39)41-26-12-8-5-9-13-26/h4-15,20,22-23,25,31,34H,16-19,21H2,1-3H3,(H,35,38)/t23-,31-/m1/s1
PubChem CID	70681021
ChEMBL	CHEMBL2011832
IUPHAR	N/A
BindingDB	50379322
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2.5 nM	PMID22305493	BindingDB,ChEMBL

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