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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	NSC228155
Molecular formula	C11H6N4O4S
IUPAC name	7-nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole
Molecular weight	290.253
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	1.3
Synonyms	113104-25-9 s8312 4-nitro-7-[(1-oxidopyridin-2-yl)sulfanyl]-2,1,3-benzoxadiazole HMS2796J10 ZINC1757986 AKOS033457659 NSC-228155 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-oxidopyridin-1-ium CHEMBL505670 SMR000448993 7-nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole MLS000756562 BDBM25469 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]pyridin-1-ium-1-olate cid_313619 Z1603365293 AC1L7NUE MolPort-027-897-785 [ Show all ]
Inchi Key	ICCFXXDUYSPKOL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H6N4O4S/c16-14-6-2-1-3-9(14)20-8-5-4-7(15(17)18)10-11(8)13-19-12-10/h1-6H
PubChem CID	313619
ChEMBL	CHEMBL505670
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	23934.1 nM	PubChem BioAssay data set	ChEMBL

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